2013 Pubs

2013 Publications

• A.M. Gonçalves, S. Mendes, D. de Sanctis, L.O. Mendes and I. Bento, "The Crystal Structure of Pseudomonas putida Azoreductase: the active site revisited." , FEBS J. (2013) 280(24):6643-6657.

• B. Correia, S.A. Cerqueira, C. Beauchemin, M. Pires de Miranda, S. Li, R. Ponnusamy, L. Rodrigues, T. R. Schneider, M. A. Carrondo, K. M. Kaye, J. P. Simas and C. E. McVey “Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency", PlosPath. (2013), 9(10): e1003673. doi:10.1371/journal.ppat.1003673.

• M. Pires de Miranda, F. B. Lopes, C. E. McVey, X. R. Bustelo,and J. P. Simas. "Role of Src-homology domain binding in signaling complexes assembled by the murid gammaherpesvirus M2 protein."J. Biol. Chem. 2013 vol. 288(6) p. 3858-3870.

Cbikp Structure Modified tetrapyrroles are key elements for life since they serve as cofactors and pigments in several biological processes. Well-known examples are hemes, siroheme, vitamin B12, coenzyme F430 and chlorophyll, whose assembly requires insertion of a specific metal ion into the tetrapyrrolic structure, via chelatase enzymes. Cobaltochelatases act in the vitamin B12 biosynthetic pathway, cobalt being inserted into the tetrapyrrole ring. The X-Ray crystallographic structure from the cobaltchelatase CbiKP from Desulfovibrio vulgaris was determined, and this is the first structure of...

2013 Publications

Structural Genomics Highligths