Merck Serono Pharma - Pre-clinical projects in the field of Structure-based drug design, encompassing methods like X-ray crystallography, Thermofluor, Limited Proteolysis, DLS, Mass Spectroscopy and Edman degradation.
Coordinator - Tiago Bandeiras
Period - Since 2005 & ongoing
Bayer - Pre-clinical projects developed in the field of Structure-based drug design. encompassing methods like X-ray crystallography, NMR, Thermofluor, DLS, Mass Spectroscopy and Edman degradation.
Period - 2005 to 2010
1. Project Title - Structural determinants of superoxide reduction - A life essential detoxification system.
Reference - PTDC/BIA-PRO/111940/2009. Period: 2011-2013
Participants - Institut Laue-Langevin, Grenoble (Professor Trevor Forsyth); ITQB (Dr. Célia Romão and Dr. Pedro Matias)
2. Project Title - Response to oxidative and nitrosative stress by Entamoeba histolytica: searching for new virulence factors
Reference - PTDC/SAU-MIC/111447/2009. Period: 2011-2013
Coordinator - Research Institute for Medicines and Pharmaceuticals Sciences, Faculty of Farmacy, UL (Dr. João Vicente)
3. Project Title -Generation of Anti-carcinogenic Antibodies by Phage Display Technology - Function blocking of anti-human jagged1 protein aiming at inhibiting the Notch1 signaling pathway.
Reference - PTDC/SAU-ONC/121670/2010. Period: 2012-2014
Coordinator - IBET (Dr. Ana Barbas)
Merck Serono Pharma , Darmstadt, Germany
Arnulf Kletzin - Sulfur Metabolism in Archaea, TU Darmstadt, Darmstadt, Germany
Prof. T. Forsyth ILL’s Neutron -Biology program in the PSB, Grenoble, France
Mónica Bettencourt-Dias - Cell Cycle Regulation, Instituto Gulbenkian de Ciência, Portugal
Cláudio Gomes - Protein Biochemistry Folding & Stability, ITQB, Portugal
Miguel Teixeira - Metalloproteins & Bioenergetics Lab., ITQB, Portugal
João Vicente - Faculdade de Farmácia, Universidade Lisboa, Lisboa, Portugal
