MX Structural Genomics Lab

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2012 Publications

• S. Gonçalves, S. P. Miller, M. A. Carrondo, A. M. Dean and P. M. Matias, "Induced Fit and the Catalytic Mechanism of Isocitrate Dehydrogenase", Biochemistry (2012), 51:7098–7115

• C.S. Silva, J.M. Damas, Z. Chen, V. Brissos, L.O. Martins, C.M. Soares, P.F. Lindley and I. Bento, “The role of Asp116 in the reductive cleavage of dioxygen to water in CotA laccase: assistance during the proton-transfer mechanism ”, Acta Cryst. (2012), D68(2): 186-193.

• C.S. Silva, P. Durão, A. Fillat, P.F. Lindley, L.O. Martins, I. Bento, “Crystal structure of the multicopper oxidase from the pathogenic bacterium Campylobacter jejuni CGUG11284: characterization of a metallo-oxidase”, Metallomics (2012), 4(1): 37-47. (Front cover

 

Books:

• M.A. Carrondo and P. Spadon (eds) “Macromolecular Crystallography: Deciphering the structure, function and dynamics of biological molecules”, NATOScience for Peace and Security Series A: Chemistry and Biology(2012),Springer: Dordrecht (ISBN 978-94-007-2529-4) XIV, 208 p. 95 illus. DOI: 10.1007/978-94-007-2530-0.

 

Book Chapters:

• S. Gorynia, T.M. Bandeiras, P.M. Matias, F.G. Pinho, C. McVey, P. Donner and M.A. Carrondo. “RuvBL1 and RuvBL2 and their complex proteins implicated in many cellular pathways”, in Macromolecular Crystallography: Deciphering the structure, function and dynamics of biological molecules (2012), (M.A Carrondo and P. Spadon, eds) NATOScience for Peace and Security Series A: Chemistry and Biology,pp. 55-63. DOI: 10.1007/978-94-007-2530-0_5.

 

Structural Genomics Highligths

Cbikp Structure highlight

Cbikp Structure Modified tetrapyrroles are key elements for life since they serve as cofactors and pigments in several biological processes. Well-known examples are hemes, siroheme, vitamin B12, coenzyme F430 and chlorophyll, whose assembly requires insertion of a specific metal ion into the tetrapyrrolic structure, via chelatase enzymes. Cobaltochelatases act in the vitamin B12 biosynthetic pathway, cobalt being inserted into the tetrapyrrole ring. The X-Ray crystallographic structure from the cobaltchelatase CbiKP from Desulfovibrio vulgaris was determined, and this is the first structure of...

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Structural Genomics | Macromolecular Crystallography Unit 2011

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