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SOR - Sulfur Oxigenase Reductase

SOR from the thermoacidophilic and chemolithotrophic archaeon A. ambivalens is the initial enzyme in its dissimilatory sulfur oxidation pathway. SOR is a self-compartment-alizing enzyme (308 aa) that disproportionates sulfur into H2S, SO32- and SSO32-, using a low-potential mono-nuclear non-heme iron centre as catalytic site, in a reaction where elemental sulfur works both as electron donor and acceptor.

 

References

Urich T, Coelho R, Kletzin A, Frazao C. The sulfur oxygenase reductase from Acidianus ambivalens is an icosatetramer as shown by crystallization and Patterson analysis. Biochim Biophys Acta. 2005 Mar 14;1747(2):267-70.

Urich T, Gomes CM, Kletzin A, Frazão C. X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme. Science. 2006 Feb 17;311(5763):996-1000.

Legend: The SOR holoenzyme. Cartoon representation viewed along the crystallographic fourfold axis. Note the protrusions at fourfold pseudo-symmetry axes.

 

Macromolecular Crystallography Unit 2016

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